Scientists have developed a smart bandage that can actively monitor chronic wounds and deliver appropriate drug treatments to improve the chances of healing.
The research, published in the journal Small, is aimed at transforming bandaging from a traditionally passive treatment into a more active paradigm to address a persistent and difficult medical challenge. Chronic skin wounds from burns, diabetes, and other medical conditions can overwhelm the regenerative capabilities of the skin and often lead to persistent infections and amputations.
With the idea of providing an assist to the natural healing process, the researchers at Tufts University in the US designed the bandages with heating elements and thermoresponsive drug carriers that can deliver tailored treatments in response to embedded pH and temperature sensors that track infection and inflammation.
Non-healing chronic wounds are a significant medical problem. Patients are often older and limited in their ability to provide self-care, yet non-healing wounds are typically treated in an outpatient setting or at home. The smart bandages could provide real-time monitoring and delivery of treatment with limited intervention from the patient or caregivers.
"We've been able to take a new approach to bandages because of the emergence of flexible electronics," said Sameer Sonkusale, a professor at Tufts University in the US.
"In fact, flexible electronics have made many wearable medical devices possible, but bandages have changed little since the beginnings of medicine. We are simply applying modern technology to an ancient art in the hopes of improving outcomes for an intractable problem," said Sonkusale.
The pH of a chronic wound is one of the key parameters for monitoring its progress. Normal healing wounds fall within the range of pH 5.5 to 6.5, whereas non-healing infected wounds can have pH well above 6.5.
Temperature is also an important parameter, providing information on the level of inflammation in and around the wound. While the smart bandages in this study combine pH and temperature sensors, researchers have also developed flexible sensors for oxygenation - another marker of healing - which can be integrated into the bandage.
Inflammation could also be tracked not just by heat, but by specific biomarkers as well. A microprocessor reads the data from the sensors and can release drug on demand from its carriers by heating the gel. The entire construct is attached to a transparent medical tape to form a flexible bandage less than 3 mm thick. Components were selected to keep the bandage low cost and disposable, except for the microprocessor, which can be re-used.
"The smart bandage we created, with pH and temperature sensors and antibiotic drug delivery, is really a prototype for a wide range of possibilities," said Sonkusale.
"One can imagine embedding other sensing components, drugs, and growth factors that treat different conditions in response to different healing markers," he said....