London: Environmental and lifestyle factors may influence the onset of puberty in humans, suggests a new study which provides a significant insight into the crucial role of epigenetic factors on our reproductive development.
To a large extent, pubertal timing is heritable, but the underlying genetic causes are still unexplained. Researchers have now studied how chemical modifications of the human genome (so-called epigenetic modifications) change when girls and boys enter puberty. The results indicate that such epigenetic changes are involved in defining the onset of puberty.
Danish girls' pubertal onset has decreased from 11 to 10 years. Similar, but less pronounced, changes have been observed in boys, researchers said. This has led researchers to question the involvement of genetics and recognise that genes are not alone in influencing a child's pubertal timing. In the new study from EDMaRC at Rigshospitalet, Copenhagen, researchers focused on the role of epigenetics and have found a number of areas in the human genome, which is
controlled epigenetically during puberty.
They found that these epigenetic changes cause the upregulation of genes that are important for pubertal development. One of the newly discovered 'puberty genes' is TRIP6 (Thyroid Hormone Receptor Interactor 6), which is increasingly
expressed through puberty, due to changes in the epigenetic control of the gene, researchers said. Epigenetics is a leading mechanism by which our environment communicates with our genes.
Environmental and lifestyle factors in the broadest sense can affect the epigenetic regulation of genes and thereby control whether, where and to what extent the genes are expressed. The identified epigenetic changes during puberty are therefore our best lead towards understanding how environmental factors can affect pubertal onset. "To our knowledge, this study is the first to demonstrate how the environment can affect the pubertal onset in humans. It gives us a significant insight in to the crucial role of epigenetic factors on our reproductive development," said Professor Anders Juul, senior author of the study.
"We've seen a tendency of especially girls starting puberty earlier than before and this study emphasises the importance of understanding the role of environmental impact on pubertal development," he said. Highly specific changes in methylation of a child's DNA could differentiate children according to whether they had entered puberty or not and thus may be used to predict a child's pubertal stage.
"Changes in the DNA methylation patterns can be caused by many different factors. However, we could see very specific changes when children went through puberty, and have subsequently shown that this also leads to changes in the expression of the methylated genes," said senior researcher in epigenetics Kristian Almstrup, who led the study.
