Hyderabad: A group of researchers from the University of Hyderabad (UoH) have designed nano drug carriers with biocompatible polymer that can impact immunotherapy and cancer treatment.
The group, lead by Dr Pradip Paik, associate professor of School of Engineering Sciences and Technology has found that the use of these carriers can ensure a sustained and prolonged release of nitric oxide in macrophages. This property of the capsule is called drug encapsulation.
The design of the capsule is such that it has a hollow poly-N-acryloyl L-phenyl alanine methylester (NAPA-HPN), which has biodegradable nanocapsules of average size ranging from 100-150 nm. The capsules can disperse the drugs for immunity in a way that their effect is sustained with maximum surface charge, thereby increasing their impact.
The group said that the NAPA-HPN nanocapsules cannot just handle the infectious and tumor diseases with dexterity but that the capsule can stimulate the immune system as well. Thus capsule could be a path-breaking development in the field of treating immunity and tumour-related diseases. The work has been published as advanced article in the Nanoscale.