Washington: An investigator from Dana-Farber Cancer Institute now says that a combination of two drugs - one of them an immunotherapy agent - could become a new standard, first-line treatment for patients with metastatic kidney cancer. The investigator made the claims after the release of results from a phase 3 clinical trial.
The study found that patients who received the immunotherapy drug avelumab plus axitinib, a targeted agent, had a significant advantage in progression-free survival compared with those who received sunitinib (Sutent), a targeted drug that has been a standard treatment for advanced clear cell renal cell carcinoma - the most common form of kidney cancer.
Speaking about it, senior and co-corresponding author of the report Toni K. Choueiri said, “Patients receiving the drug combination also had a higher response rate - meaning their tumours shrank - than the sunitinib-only group.”
While progression-free survival was improved with the combination treatment, additional follow-up is needed to show whether the two-drug therapy extends overall survival compared to the standard regimen.
The trial is the first pivotal study to combine avelumab with a drug that targets the vascular endothelial growth factor receptor (VEGFR). VEGFR blockers like sunitinib and axitinib are designed to starve tumours by disrupting their blood supply. The clinical trial involved 886 patients with previously untreated, advanced renal cell carcinoma who were randomised to receive the drug combination or sunitinib alone.
Choueiri said that for patients with advanced disease, "this is an important option. What we're doing in advanced kidney cancers is pushing the envelope - these treatments may not be curative, but patients are living longer, and the disease is becoming more chronic."
