London: A specialised white blood cell found in birds can destroy a potentially fatal fungal infection which affects over one million people every year, according to a new study.
Cryptococcus neoformans is one of the most dangerous infections affecting individuals with AIDS and is thought to cause hundreds of thousands of deaths worldwide, every year. The fungus causes fatal infections in those with a weakened immune system. Birds are known to carry the fungus and their droppings are thought to be a source of human infection; however it has been a longstanding mystery why the birds themselves do not appear to become ill.
Now, a team from the University of Sheffield have shown that a particular white blood cell within the bird's blood system, called a macrophage, is able to completely block the growth of Cryptococci.
According to a statement by the University, the scientists, led by Dr Simon Johnston, found that the fungus can grow slowly within the bird's digestive tract, but if it tries to invade the bird's body then the immune system immediately destroys it which explains why healthy birds can still help spread the infection.
Johnston said: "Birds have a higher body temperature than humans, 42 degree Celsius instead of 37 degree Celsius, but this alone is not enough to fully stop the fungus." "By studying bird cells under the microscope, we have seen that macrophage cells have the ability to completely block the growth of the fungus, which can be fatal in humans.
Understanding where the disease comes from and how it spreads is critical," Johnston said. He also said if it could be found how some animals are able to resist infection then further insights can be gained into how to improve the human immune response to this fungus.
This work, published in Nature Scientific Reports, was carried out in collaboration with the University of Birmingham and is part of a much larger international effort to understand, fight and ultimately eliminate cryptococcosis.
"Many human diseases are spread by birds, but we know surprisingly little about their immune systems. Discovering how they resist otherwise fatal infections offers the hope of improving our ability to intervene in this cycle and prevent a diverse range of human diseases," Johnston said.
He added: "In addition, infectious diseases of birds themselves are a major threat to agriculture, such as when 170,000 poultry were culled due a suspected bird flu
outbreak."
