Prince Frederik of Luxembourg Dies at 22 from Rare Genetic Disorder
Young royal succumbed to POLG mitochondrial disease; family honors his legacy
By : DC Correspondent
Update: 2025-03-10 04:29 GMT
Prince Frederik of Luxembourg, the youngest son of Prince Robert of Luxembourg and Princess Julie of Nassau, passed away on March 1 at the age of 22. The prince succumbed to POLG mitochondrial disease, a rare genetic disorder he had been battling since birth.
Born on May 18, 2002, Prince Frederik was diagnosed with POLG mitochondrial disease at the age of 14. This condition impairs the body's ability to produce energy, leading to progressive organ failure. Despite his diagnosis, Frederik remained resilient and dedicated his life to raising awareness about the disease. He established the POLG Foundation to support research and advocate for those affected by mitochondrial disorders.
In a heartfelt statement on the POLG Foundation's website, Prince Robert reflected on his son's final moments, noting that Frederik spent his last day, which coincided with Rare Disease Day, surrounded by family. Despite his deteriorating health, Frederik maintained his humor and compassion, leaving his loved ones with a final joke to lift their spirits. Prince Robert expressed immense pride in his son's courage and contributions, referring to him as his "superhero."
Frederik's commitment to the POLG Foundation led to significant advancements in research. He collaborated with international scientists, developed mouse models and cell lines, and launched initiatives like the MITO clothing line to fund research efforts. His endeavors have been instrumental in furthering the understanding of mitochondrial diseases and inspiring the global community.
The prince's passing has elicited condolences from around the world. The Grand Ducal Family of Luxembourg expressed deep sorrow, highlighting Frederik's unwavering spirit and dedication to helping others. Friends and supporters have taken to social media to share memories and pay tribute to his legacy.
POLG mitochondrial disease affects approximately 300 million people worldwide and currently has no cure. Symptoms include muscle weakness, seizures, and organ failure, with severity varying among individuals. Frederik's advocacy brought attention to the challenges faced by those with rare genetic disorders and underscored the need for continued research and support.
In honoring Prince Frederik's memory, his family has requested that donations be made to the POLG Foundation to continue the work he was so passionate about. They hope to carry forward his mission of finding a cure and providing hope to others affected by mitochondrial diseases.
Prince Frederik's life, though short, was marked by resilience, compassion, and a steadfast commitment to making a difference. His legacy will continue to inspire and drive efforts in the fight against mitochondrial diseases.