Genetic basis found in Ayurveda

 

The expansive study to dig into the molecular and genetic basis of  medicinal practices of Ayurveda was carried out by researchers from  Hyderabad- based Centre for Cellular and Molecular Biology (CCMB),  Manipal University, Indian Institute of Science and other institutes.  

 

CCMB scientists announced that they have identified the gene PGM1 associated with the Pitta dosha. Pitta dosha is one of the three doshas defined in the Charaka Samhita -- the other two being Vata and  Kapha.

 

Scientists explained that 3,416 patients from across the country were assessed by Ayurvedic doctors engaged in the study. Of them, 262 were  predominantly characterised by one of the three doshas. "The analysis resulted in formation of three groups with each of the doshas. And, we have found that the three doshas have a molecular basis," CCMB  director Dr Ch Mohan Rao said, adding, "We found that about 52  gene-markers are important in deciding which dosha group a person will belong to. And, one gene in particular is associated with the Pitta  dosha."

 

Ancient texts have described Pitta dosha as one dominating all heat,  metabolism and transformation. The associated gene, PGM1, is also  known to be central to controlling the Basal Metabolism Rate (BMR). Scientists are looking to identify the genes associated with the other two doshas. CCMB senior principal scientist and co-author of the study  

 

Dr K Thangaraj explained, “We have identified the gene associated with  Pitta but further studies are required for the remaining two.” Dr Mohan Rao said the findings are extremely important and should  inspire others to take up similar studies. He also said the findings  are crucial to the development of personalised medicine in the future.