New imaging method could help in breast cancer treatment

London: Scientists have developed a simple and non-invasive imaging method for defining appropriateness of breast cancer treatment which is as accurate as the current techniques. The method could reduce the need for invasive tissue sampling and lead to more optimal treatment of individual patients, researchers said. Measuring the growth factor HER2 (human epidermal growth factor receptor type 2) is an important tool for deciding correct treatment in breast cancer, researchers said.

Treatments targeting HER2 are expensive but save the lives of many women. Targeted treatments have no effect if the metastases do not express HER2. The current diagnosis of elevated HER2 expression in metastatic cancer is based on examination of tissue samples obtained by surgery or needle biopsies from the liver, bones and other organs. Researchers from Uppsala University in Sweden wanted to develop a simpler and non-invasive technique, based on whole-body PET/CT imaging, and compare the results of image analysis to the invasive measurements in the same patients.

The study included 16 women with on-going treatment of metastatic breast cancer. Twelve had been diagnosed with a HER2-positive primary tumour and four were HER2-negative. All patients were scanned using combined PET/CT and a novel tracer molecule, ABY-025 Affibody, labelled with the short-lived radioactive isotope gallium-68. The results showed that the amount of HER2-expression in the metastases was accurately measured with the new method. In addition, the amount of HER2-expression in the

metastases was frequently found to be different from the primary tumour, leading to a change in therapy in several patients.

The new method might substitute invasive tissue sampling in the near future. "Our study resulted in two patients starting therapy and one patient ending therapy with HER2-targeting drugs," said Jens Sorensen, PET-researcher and adjunct professor at the Institution of Surgical Sciences at Uppsala University. The research group now plans a larger study with more participating hospitals to confirm the results with the intention of making the new method more widely available to patients. The study was published in the journal Theranostics.