New York: Rafael Nadal made his earliest US Open exit in a decade Friday, suffering his first Grand Slam defeat after leading by two sets, while Serena Williams rallied to keep her calendar Slam dream alive.
Spanish eighth seed Nadal, whose 14 Slam titles include the 2010 and 2013 US Open crowns, fell victim to 32nd-seeded Italian Fabio Fognini 3-6, 4-6, 6-4, 6-3, 6-4 at Arthur Ashe Stadium.
Nadal had not lost so early on the New York hardcourts since a third-round ouster in 2005 by American James Blake. The 29-year-old left-hander had been 151-0 in Slam matches when leading by two sets.
But Fognini imposed seven consecutive service breaks upon Nadal in the fourth and fifth sets, smacking 70 winners past the iconic star in a fantastic effort.
"I can't describe how happy I am," Fognini said. "It was very tough. To do it against Rafa, two sets down. It was an incredible match."
Fognini, 32, booked a last-16 date with 18th-seeded Spaniard Feliciano Lopez, who eliminated Canadian 10th seed Milos Raonic 6-2, 7-6 (7/4), 6-3.
Nadal lost to Fognini on clay at Rio de Janeiro and Barcelona earlier this year, but had bounced back with a triumph in July's Hamburg final.
It was Fognini's first win in 18 tries on hardcourt against a top-10 rival and made him the first Italian in the US Open last 16 since Davide Sanguinetti in 2005.
Women's world number one Williams, meanwhile, battled through mistakes and the tension of her quest for tennis history.
Williams fought back to defeat 101st-ranked US compatriot Bethanie Mattek-Sands 3-6, 7-5, 6-0 at Arthur Ashe Stadium and needs only four more triumphs to complete the first calendar Slam since Steffi Graf in 1988.
Williams, holder of all four major titles, also seeks her 22nd career Slam singles crown to match Graf's Open Era record and move two shy of Australian Margaret Court's all-time mark.
The 33-year-old American went to three sets for the 10th time in 24 Grand Slam matches this year and stayed perfect, eight of those fightbacks after first-set defeats.
"I'm not trying to live on the edge," Williams said. "I don't think I came out too slow. I think Bethanie came out really well. I had to adapt to her game and I finally got some rhythm going toward the end of the second set."
Williams struggled with her first serve early, hitting only 52 percent in the first set, when she also made half of her 28 unforced errors, but Williams found her form late in the second set and dominated from there.
"She stepped up," Mattek-Sands said. "She's a great closer. She always has been. You can see when she's confident in her shots."
Three-time defending champion Williams, who could reach her first Grand Slam final without facing a top-10 foe, next plays US 19th seed Madison Keys.
Djokovic, Cilic advance:
Top-ranked Novak Djokovic moved a step closer to his 10th career Slam crown and third of the year by defeating Italy's Andreas Seppi 6-3, 7-5, 7-5.
Djokovic took his 31st win in a row over Italian foes, 11 of them against Seppi, since losing to Filippo Volandri in his ATP debut at Umag in 2004.
"It was a tough three sets," Djokovic said. "Just hanging in there. Be patient for your opportunities. You try to cash in when they come."
Next up is Spanish 23rd seed Roberto Bautista Agut, who advanced when 14th-seeded Belgian David Goffin retired while leading 6-2, 7-5, 3-6, 1-3.
A Grand Slam record 13 men have retired from matches at this tournament, many from heat-related cramping issues.
Croatian ninth seed Marin Cilic barely escaped making the earliest exit of any defending champion since Andre Agassi in 1999 before outlasting 56th-ranked Kazak Mikhail Kukushkin 6-7 (5/7), 7-6 (7/1), 6-3, 6-7 (3/7), 6-1.
"It wasn't easy but I stayed together and got it done," Cilic said.
Cilic next meets French 27th seed Jeremy Chardy, who ousted Spanish seventh seed David Ferrer 7-6 (8/6) 4-6, 6-3, 6-1.
Venus eases Serena's path:
Venus Williams, 35, eased sister Serena's path to the final by ousting the top-rated rival on their side of the draw, defeating 12th-seeded Swiss teen Belinda Bencic 6-3, 6-4.
Bencic, 18, inflicted the most recent defeat upon Serena last month in a Toronto semi-final, but fell to 0-4 against Venus, who fired 31 winners against 15 unforced errors.
"I just wanted to be aggressive," Venus said. "Keeping the errors down really helped me close out the match."
Venus, seeded 23rd, reached a fourth-round match against 152nd-ranked Estonian teen qualifier Anett Kontaveit and could face Serena after that.
"I hope we both get to the quarter-finals," Venus said....