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Concussions may lead to Alzheimer's disease

Published Dec 27, 2013, 6:39 pm IST
Updated Mar 19, 2019, 3:02 am IST
Concussions may lead to Alzheimer's disease.

A new study has suggested that a history of concussion involving at least a momentary loss of consciousness could be related to the onset of Alzheimer's-associated plaques in the brain.

Study author Michelle Mielke, PhD, with Mayo Clinic in Rochester, Minnesota, said that in people with a history of concussion, a difference in the amount of brain plaques was found only in those with memory and thinking problems, not in those who were cognitively normal.


For the study, people from Olmsted County in Minnesota were given brain scans; these included 448 people without any signs of memory problems and 141 people with memory and thinking problems called mild cognitive impairment.

Participants, who were all age 70 or older, were also asked about whether they had ever experienced a brain injury that involved any loss of consciousness or memory.

Of the 448 people without any thinking or memory problems, 17 percent reported a brain injury and 18 percent of the 141 with memory and thinking difficulties reported a concussion or head trauma.


The study found no difference in any brain scan measures among the people without memory and thinking impairments, whether or not they had head trauma.

However, people with memory and thinking impairments and a history of head trauma had levels of amyloid plaques an average of 18 percent higher than those with no head trauma history.

The research has been published online in journal Neurology.