Chemotherapy could allow cancer to spread, and trigger more aggressive tumours, a new study suggests. Researchers in the US studied the impact of drugs on patients with breast cancer and found medication increases the chance of cancer cells migrating to other parts of the body, where they are almost always lethal.
Around 55,000 women are diagnosed with breast cancer in Britain every year and 11,000 will die from their illness. Many are given chemotherapy before surgery, but the new study suggests that, although it shrinks tumours in the short term, it could trigger the spread of cancer cells.
It is thought the toxic medication switches on a repair mechanism in the body which ultimately allows tumours to grow back stronger. It also increases the number of ‘doorways’ on blood vessels which allow cancer to spread throughout the body.
Dr George Karagiannis, of the Albert Einstein College of Medicine of Yeshiva University, New York, found the number of doorways was increased in 20 patients receiving two common chemotherapy drugs. He also discovered that in mice, breast cancer chemotherapy increased the number of cancer cells circulating the body and in the lungs.